Morris Loeb Professor, Department of Chemistry and Chemical Biology at Harvard University; Cofounder at Broad Institute
Stuart Schreiber is the Morris Loeb Professor of Chemistry and Chemical Biology at Harvard University, a co-Founder of the Broad Institute, and a member of the National Academy of Sciences, National Academy of Medicine and American Academy of Arts and Sciences.
His lab integrates chemical biology and human biology to advance the science of therapeutics. He is known for having developed systematic ways to explore biology, especially disease biology, using small molecules and for his role in the development of the field of chemical biology. Key advances include the finding that small molecules can function as “molecular glues” that promote protein–protein interactions, the discovery of mTOR and its role in nutrient-response signaling, and the discovery of histone deacetylases and that chromatin marks regulate gene expression. His research has been acknowledged through awards including the Wolf Prize in Chemistry and the Arthur Cope Award. His approach to therapeutics discovery guided the development of many biotechnology companies that he founded including Vertex Pharmaceuticals and Ariad Pharmaceuticals